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MRK 016, Tocris Bioscience™

Catalog No. 381750
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

α5-selective GABAA inverse agonist

GABAA receptor inverse agonist selective for the α5-subtype (EC50 = 3 nM). Exhibits affinity at benzodiazepine binding site of recombinant human GABAA receptors (Ki values are 0.77 nM, 0.83 nM, 0.85 nM and 1.4 nM for α3-, α1-, α2-, and α5-containing respectively). Increases long-term potentiation (LTP) in mouse hippocampal slices. Exhibits no anxiogenic or proconvulsant activity.

Chemical Identifiers

CAS 783331-24-8
Molecular Formula C17H20N8O2
Molecular Weight (g/mol) 368.401
InChI Key QYSYOGCIDRANAR-UHFFFAOYSA-N
Synonym d09ihe, 2-1-methyl-1h-1,2,4-triazole-5-yl methoxy-3-tert-butyl-7-5-methyl-3-isoxazolyl pyrazolo 1,5-d 1,2,4 triazine, 3-1,1-dimethylethyl-7-5-methyl-3-isoxazolyl-2-1-methyl-1h-1,2,4-triazol-5-yl methoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-3-tert-butyl-2-2-methyl-1,2,4-triazol-3-yl methoxy pyrazolo 1,5-d 1,2,4 triazin-7-yl-5-methyl-1,2-oxazole, 3-t-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy-pyrazolo 1,5-d-1,2,4 triazine, 3-tert-butyl-7-5-methyl-isoxazol-3-yl-2-2-methyl-2h-1,2,4 triazol-3-ylmethoxy-pyrazolo 1,5-d 1,2,4 triazine, 3-tert-butyl-7-5-methylisoxazol-3-yl-2-1-methyl-1h-1,2,4-triazol-5-ylmethoxy pyrazolo 1,5-d 1,2,4-triazine, 5-3-tert-butyl-7-5-methyl-1,2-oxazol-3-yl pyrazolo 1,5-d 1,2,4 triazin-2-yl oxy methyl-1-methyl-1h-1,2,4-triazole
PubChem CID 6918583
IUPAC Name 3-[3-tert-butyl-2-[(2-methyl-1,2,4-triazol-3-yl)methoxy]pyrazolo[1,5-d][1,2,4]triazin-7-yl]-5-methyl-1,2-oxazole
SMILES CC1=CC(=NO1)C2=NN=CC3=C(C(=NN32)OCC4=NC=NN4C)C(C)(C)C

Specifications

Quantity 50 mg
Formula Weight 368.39
Percent Purity >98%
Chemical Name or Material MRK 016

Safety and Handling

Recommended Storage Store at +4°C
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