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RS 504393, Tocris Bioscience™

Catalog No. 251710
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Highly selective CCR2 chemokine receptor antagonist

Extremely selective CCR2 chemokine receptor antagonist (IC50 values are 98 nM and > 100 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Inhibits MCP-1 chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.

Chemical Identifiers

CAS 300816-15-3
Molecular Formula C25H27N3O3
Molecular Weight (g/mol) 417.509
InChI Key ODNICNWASXKNNQ-UHFFFAOYSA-N
Synonym 6-methyl-1'-2-5-methyl-2-phenyloxazol-4-yl ethyl spiro benzo d 1,3 oxazine-4,4'-piperidin-2 1h-one, 6-methyl-1'-2-5-methyl-2-phenyl-4-oxazolyl ethyl spiro 4h-3,1-benzoxazine-4,4'-piperidin-2 1h-one, 6-methyl-1'-2-5-methyl-2-phenyloxazol-4-yl ethyl spiro-benzo d 1,3 oxazine-4,4'-piperidin-2 1h-one, 6-methyl-1'-2-5-methyl-2-phenyl-1,3-oxazol-4-yl ethyl-1h-spiro 3,1-benzoxazine-4,4'-piperidin-2-one, acmc-20a25e, d0x4si, gtpl781, 6-methyl-1-2-5-methyl-2-phenyl-1,3-oxazol-4-yl ethyl spiro 1,4-dihydro-2h-benzo d 1,3 oxazine-4,4-hexahydropyridine-2-one, 6-methyl-1'-2-5-methyl-2-phenyl-1,3-oxazol-4-yl ethyl-1,2-dihydrospiro 3,1-benzoxazine-4,4'-piperidine-2-one, 6-methyl-1'-2-5-methyl-2-phenyl-1,3-oxazol-4-yl ethyl spiro 3,1-benzoxazine-4,4'-piperidin-2 1h-one
PubChem CID 9953769
IUPAC Name 6-methyl-1'-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethyl]spiro[1H-3,1-benzoxazine-4,4'-piperidine]-2-one
SMILES CC1=CC2=C(C=C1)NC(=O)OC23CCN(CC3)CCC4=C(OC(=N4)C5=CC=CC=C5)C

Specifications

Quantity 10 mg
Formula Weight 417.5
Percent Purity >99%
Chemical Name or Material RS 504393

Safety and Handling

Recommended Storage Store at +4°C
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